12 Sandwiches Worth the Road Trip

Ready to plan your next food adventure? These twelve sandwiches are worth every mile; each one represents the very best of its region, and every bite is a memory in the making.

North Shore Beef

Two North Shore Beef sandwiches with thick slices of meat, melted cheese, onions, and barbecue sauce overflowing from sesame seed buns are served on a baking sheet.
Maddy Alewine/Them Bites

Massachusetts’ thin-sliced roast beef; topped with mayo and lathered in James River BBQ Sauce and stacked in a soft roll for the juiciest road food you’ll ever eat.

Fried Pork Tenderloin Sandwich

A crispy Fried Pork Tenderloin Sandwich with lettuce, tomato, and a sesame seed bun, placed on a wooden board.
Maddy Alewine/Them Bites

Indiana’s sandwich has a breaded pork tenderloin so big it hangs over the edges; crunchy, meaty, and worth every mile.

Muffuletta Sandwich

muffuletta
Maddy Alewine/Them Bites

New Orleans’ massive round loaf filled with meats, cheese, and olive salad; salty and savory, it’s a sandwich adventure all by itself.

Pueblo Slopper

slopper
Maddy Alewine/Them Bites

Open-faced cheeseburger smothered in spicy green chili; Colorado’s answer to bold and messy comfort food.

Fish Fry Sandwich

beer battered fried fish
Maddy Alewine/Them Bites

Crispy fried fish, lettuce, and tartar sauce on a bun; perfect for lakeside drives and Friday cravings.

Liver Mush Sandwich

A hand holds half of a livermush sandwich with two beef patties and a bun, showing the cross-section. The other sandwich half and a large knife rest on a wooden cutting board in the background.
Maddy Alewine/Them Bites

North Carolina’s crispy-fried pork and cornmeal patty on white bread; local comfort you can only find in the South.

Bison Burger

bison burger
Maddy Alewine/Them Bites

Lean, juicy bison patty, sharp cheese, and a toasted bun; a Western specialty with deep flavor.

Pastrami Burger

pastrami burger
Maddy Alewine/Them Bites

Utah’s best burger, topped with pastrami and cheese; this stop will ruin ordinary burgers forever.

Panes con Pollo

Two Panes Con Pollo sub sandwiches filled with shredded seasoned chicken, lettuce, sliced cucumber, radish, and tomato, served on whole wheat rolls, placed on a wooden cutting board.
Maddy Alewine/Them Bites

Roast chicken, slaw, and tangy sauce in a crusty roll; a Salvadoran street food adventure right in your hands.

Patty Melt

A close-up of a crab cake sandwich with a golden brown bun, leafy lettuce, sliced green pepper, and a thick, seasoned patty on a wooden surface.
Maddy Alewine/Them Bites

Beef patty, Swiss cheese, onions, and rye; grilled until golden brown and gooey—classic diner nostalgia at its best.

French Dip Sandwich

Maddy Alewine/Them Bites

Roast beef, chewy roll, and hot au jus for dipping; it’s warm, savory, and absolutely unforgettable on any trip.

Crab Cake Sandwich

Maddy Alewine/Them Bites

Maryland’s crab cake, lettuce, tomato, and tartar on a bun; coastal comfort food worth detouring for.

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