12 Sandwiches That Showcase Regional Favorites

Every state and city has its own sandwich that locals can’t live without. These sandwiches don’t just fill bellies, they tell stories about the people and places that created them. Here are twelve regional favorites that deserve the spotlight.

Pepperoni Rolls

pepperoni rolls out of the oven
Maddy Alewine/Them Bites

Pepperoni rolls were designed for West Virginia miners but remain a snack for everyone today. Soft bread wrapped around pepperoni keeps this tradition alive. Get the recipe here.

Horseshoe Sandwich

Crinkle-cut French fries and a burger patty on a plate, topped with a generous drizzle of creamy yellow cheese sauce being poured from above—just like in a classic Horseshoe Sandwich Recipe.
Maddy Alewine/Them Bites

Born in Springfield, Illinois, the Horseshoe is a massive plate of toast, meat, fries, and cheese sauce. It’s over the top, but that’s exactly why locals love it. Get the recipe here.

Pastrami Burger

pastrami burger
Maddy Alewine/Them Bites

Utah’s signature twist, the pastrami burger stacks salty pastrami over a juicy burger. It’s hearty, unique, and a proud staple in the state’s food culture. Get the recipe here.

Cuban Sandwich

A close-up of two hands holding a halved Cubano, showing layers of roast pork, ham, Swiss cheese, pickles, and mustard between toasted bread.
Maddy Alewine/Them Bites

Miami brings the Cuban to the table, with layers of roast pork, ham, pickles, cheese, and mustard pressed flat. It’s crispy, tangy, and full of South Florida pride. Get the recipe here.

Runza

A white bowl filled with freshly baked golden brown runza bread rolls sits on a white cloth on a dark wooden table.
Maddy Alewine/Them Bites

Nebraska’s Runza is dough stuffed with beef, cabbage, and onions. It’s warm, portable, and built for feeding hungry Midwestern families. Get the recipe here.

Seattle Dog

A person holds a Seattle-Style Hot Dog in a bun topped with chopped grilled onions and green peppers. Another hot dog with similar toppings sits on a plate in the background.
Maddy Alewine/Them Bites

Seattle loves cream cheese on hot dogs, and the Seattle Dog proves why. Topped with grilled onions and tucked into a bun, it’s quirky but irresistible. Get the recipe here.

Beef on Weck

A beef on weck from the side, so you can see the entire sandwich.
Maddy Alewine/Them Bites

Buffalo puts roast beef on a kummelweck roll dusted with caraway and salt. Juicy beef and a salty crust make this sandwich unforgettable. Get the recipe here.

Chow Mein Sandwich

A white plate with a Chow Mein Sandwich—noodles, chicken pieces, sliced vegetables, and a hamburger bun on top—set on a gray surface with a plain background.
Maddy Alewine/Them Bites

From Fall River, Massachusetts, comes the Chow Mein Sandwich, stuffing noodles between a bun. It’s unusual, but locals consider it a piece of history. Get the recipe here.

Navajo Taco

navajo taco
Maddy Alewine/Them Bites

New Mexico serves the Navajo Taco on fry bread, topped with seasoned meat, beans, lettuce, and cheese. It’s a true taste of the Southwest. Get the recipe here.

Crab Cake Sandwich

tomato sandwich
Maddy Alewine/Them Bites

Maryland seafood shines in the crab cake sandwich, where sweet crab is served simply on a bun. It’s a coastal treasure that never gets old. Get the recipe here.

North Shore Beef

Maddy Alewine/Them Bites

This Massachusetts favorite stacks rare roast beef with mayo, cheese, and barbecue sauce. It’s messy, bold, and loved by generations. Get the recipe here.

Tomato Sandwich

Maddy Alewine/Them Bites

In the South, fresh tomatoes and mayo on soft bread create a sandwich that screams summer. Simple, classic, and refreshing. Get the recipe here.

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