16 Delicious Sandwiches You Can’t Afford to Miss

When you’re craving something special, these sandwiches deliver big. Packed with local flair and memorable details, each one on this list stands as a reason to eat with both hands. Don’t let these sandwiches slip by;they’re must-tries for anyone who loves real food.

Chicken Spiedie

Maddy Alewine/Them Bites

A Binghamton, New York staple, marinated chicken is grilled and piled into a soft roll, then finished with extra marinade for a zesty, juicy punch. It’s backyard barbecue at its best. GET THE RECIPE

Turkey Reuben

Maddy Alewine/Them Bites

Swapping out corned beef for tender turkey, this twist on the classic Reuben gets stacked with sauerkraut, Swiss cheese, and creamy Russian dressing between slices of rye, then grilled to golden perfection. GET THE RECIPE

Patty Melt

Maddy Alewine/Them Bites

Ground beef patty, caramelized onions, and melty cheese between slices of rye, cooked on a griddle for a crisp finish. A diner staple that’s anything but ordinary. GET THE RECIPE

Olive Burger

Maddy Alewine/Them Bites

Michigan’s quirky burger mixes chopped olives and mayo into a tangy topping for juicy beef patties. It’s unique, briny, and full of Midwestern charm. GET THE RECIPE

Runza

Maddy Alewine/Them Bites

Nebraska’s answer to a handheld pie, this stuffed bread pocket is filled with seasoned beef and cabbage. It’s simple, hearty, and unforgettable. GET THE RECIPE

Steak Bomb

Maddy Alewine/Them Bites

New England’s over-the-top sub: shaved steak, peppers, onions, mushrooms, and melted cheese all stuffed into a soft roll. It’s as filling as it is satisfying. GET THE RECIPE

Bison Burger

Maddy Alewine/Them Bites

Lean, juicy bison is grilled and served with sharp cheddar and onions, often on a toasted bun. It’s a meaty, slightly sweet burger you won’t want to miss. GET THE RECIPE

Crab Melt

Maddy Alewine/Them Bites

Thick crab cakes topped with cheese and broiled until bubbling, then placed on toasted bread. Maryland’s seafood specialty shines in every bite. GET THE RECIPE

Shrimp Po Boy

Maddy Alewine/Them Bites

New Orleans knows how to do seafood: crispy fried shrimp, lettuce, tomato, and spicy remoulade loaded into a chewy baguette. It’s bold and impossible to resist. GET THE RECIPE

French Dip Sandwich

Maddy Alewine/Them Bites

Tender roast beef stacked on a French roll, served with a bowl of rich, salty au jus for dunking. It’s pure sandwich bliss, right from Los Angeles. GET THE RECIPE

Fried Chicken Biscuit

Maddy Alewine/Them Bites

Southern-style buttermilk biscuit filled with crispy fried chicken, drizzled with honey or hot sauce for extra kick. It’s comfort food at its finest. GET THE RECIPE

Beef on Weck

Maddy Alewine/Them Bites

Buffalo’s iconic roast beef sandwich served on a kummelweck roll with horseradish and au jus. The crunch, spice, and juicy beef make it one of a kind. GET THE RECIPE

Cudighi Sandwich

Maddy Alewine/Them Bites

The Upper Peninsula’s spicy Italian sausage links with peppers and onions on a crusty roll. It’s meaty, spicy, and local to Michigan. GET THE RECIPE

Pepperoni Rolls

Maddy Alewine/Them Bites

West Virginia’s grab-and-go classic—pillowy rolls stuffed with pepperoni, perfect for picnics or lunch boxes. Simple, filling, and so good. GET THE RECIPE

Loose Meat Sandwich

Maddy Alewine/Them Bites

Iowa’s answer to the hamburger, featuring seasoned ground beef crumbled onto a bun, topped with onions and pickles. Messy, delicious, and truly comforting. GET THE RECIPE

St. Paul Sandwich

Maddy Alewine/Them Bites

St. Louis’s quirky take on egg foo young, tucked into white bread with lettuce, pickles, and mayo. It’s a fusion sandwich that surprises and delights. GET THE RECIPE

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