16 Sandwiches That Will Make Your Mouth Water Instantly

When a sandwich hits the sweet spot of being hot, crispy, juicy, and packed with bold fillings, it’s nearly impossible to wait for that first bite. These 16 picks come from all over the country and each one delivers a drool-worthy combination of texture and taste. Whether you’re craving something cheesy, meaty, spicy, or sweet, there’s a sandwich on this list that will have you reaching for a napkin before you even finish reading.

Pueblo Slopper

A burger smothered in spicy green chile sauce, this Colorado classic is as messy as it is delicious. Served open-faced with a pile of chopped onions and a fork, the Pueblo Slopper brings heat, richness, and total satisfaction. GET THE RECIPE

Shrimp Po Boy

French bread loaded with golden-fried shrimp, shredded lettuce, tomatoes, and a creamy remoulade. This Louisiana favorite offers crunch, spice, and coastal comfort in every bite. GET THE RECIPE

Cuban Sandwich

Pressed until crisp and packed with roast pork, turkey, Swiss cheese, pickles, and mustard. This Miami-born sandwich is all about contrast and crunch. GET THE RECIPE

Fried Chicken Biscuit

Golden fried chicken sandwiched inside a buttery biscuit. Sometimes drizzled with honey or hot sauce, this Southern heavyweight never disappoints. GET THE RECIPE

Loose Meat Sandwich

Seasoned ground beef piled onto a bun without being shaped into a patty. Topped with pickles and mustard, it’s messy, beefy, and beloved in Iowa. GET THE RECIPE

North Shore Beef Sandwich

Rare roast beef piled high on an onion roll slathered in mayo and drenched in James River BBQ sauce. This Massachusetts original is sloppy, savory, and unforgettable. GET THE RECIPE

Crab Cake Sandwich

Jumbo lump crab cakes on a bun with lettuce, tomato, and a dollop of tartar sauce. Straight out of Maryland and perfect for seafood lovers. GET THE RECIPE

Chicken Spiedie Sandwich

Chunks of chicken marinated in zesty Italian dressing, grilled, and served in a hoagie roll. It’s a Binghamton original that packs bright and bold flavors. GET THE RECIPE

Smoked Bologna Sandwich

Thick-sliced bologna, smoked and seared to crispy perfection, then stuffed into soft bread with mustard. Simple, smoky, and deeply comforting. GET THE RECIPE

Beef on Weck

Slow-roasted beef served on a salty kummelweck roll and finished with horseradish and jus. A Western New York legend. GET THE RECIPE

Liver Mush Sandwich

Crispy fried slices of liver mush paired with mustard on white bread. A staple in North Carolina that hits way harder than you’d expect. GET THE RECIPE

Fluffernutter

A nostalgic sandwich of peanut butter and marshmallow fluff. It’s sticky, sweet, and downright addictive. GET THE RECIPE

Hot Brown

Open-faced turkey sandwich smothered in Mornay sauce, then broiled until bubbly and golden. A Louisville icon that eats like a warm casserole. GET THE RECIPE

Cudighi Sandwich

This Upper Peninsula favorite features an Italian sausage patty with mozzarella and red sauce. Bold and hearty, it’s as warming as a bowl of pasta. GET THE RECIPE

Chicken Fried Steak Sandwich

Crunchy, peppery breaded steak served on a bun and covered with white gravy. It’s Southern indulgence in sandwich form. GET THE RECIPE