11 Regional Sandwiches Worth a Special Trip

America’s sandwich scene is filled with local treasures that can only be truly appreciated in their hometowns. These 11 sandwiches are so iconic, you’ll want to plan a getaway just to taste the real thing.

Beef on Weck

Buffalo’s prized sandwich: rare roast beef layered on a salty kummelweck roll, finished with horseradish. It’s impossible to duplicate outside Western New York. Try Beef on Weck

Pueblo Slopper

This Colorado classic is a cheeseburger drowned in green chile and onions. Forks required, napkins mandatory. Get the Slopper

Muffuletta Sandwich

Layers of cured meats, provolone, and olive salad on a massive sesame loaf. The official sandwich of New Orleans street parties. Try Muffuletta

Primanti Brothers Sandwich

Pittsburgh’s most beloved sandwich—meat, fries, coleslaw, and tomato all stacked between two slices of Italian bread. It’s a full meal in every bite. Get the Primanti

Detroit Coney Dog

Steamed bun, natural-casing hot dog, spicy chili, yellow mustard, and onions. Detroit’s legendary roadside stop. Try the Coney Dog

Loose Meat Sandwich

Seasoned ground beef, onions, and pickles piled in a bun. Iowa’s contribution to lunch counter history. Get Loose Meat

Hot Brown Sandwich

Louisville’s brunch royalty: turkey, bacon, tomato, and bubbling cheese sauce, all served open-faced. Try Hot Brown

North Shore Beef

Rare roast beef, soft onion roll, and plenty of sauce, cheese, and mayo. Massachusetts locals know this one is pure gold. Get North Shore Beef

Runza

Nebraska’s grab-and-go legend—yeast dough stuffed with beef, cabbage, and onions. The road trip pocket you never knew you needed. Try Runza

Italian Beef Sandwich

Thin-sliced beef, au jus-soaked bread, and spicy giardiniera. Chicago’s messy, meaty claim to fame. Get Italian Beef

St. Paul Sandwich

Egg foo young patty, lettuce, pickles, and mayo on white bread. St. Louis, Missouri’s wild and wonderful specialty. Get St. Paul Sandwich